Signaling and Browning in White Adipose Tissues by the Receptors for Short-Chain Fatty Acids

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15348
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: Araki Eiichi 熊本大学, 大学院生命科学研究部(医), 教授 (10253733)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ブラウニング / 短鎖脂肪酸 / 肥満 / 内臓脂肪 / 皮下脂肪 / GPR43

Outline of Final Research Achievements

The induction of beige adipogenesis within white adipose tissue (WAT), known as “browning”, has received attention as a novel anti-obesity strategy. Although acetate could exhibit anti-obesity effect and induce browning of WAT in obese diabetic KK-Ay mice, the contribution of GRP43, a receptor for acetate, on acetate-induced browning, was unknown.
In the present study, it was investigated whether orally administered acetate or butyrate could induce anti-obese effects, genes involved in browning, and browning of WAT in either high fat diet-fed GRP43-deficient or the control mice. In addition, the effects of acetate or butyrate on gene expression were investigated in primary-cultured adipocytes derived from WAT of GRP43-deficient or the control mice.
Treatment with acetate or butyrate induced anti-obesity effect and browning of WAT in both high fat diet-fed mice and upregulated genes involved in browning in either adipocytes, suggesting the GRP43-independent mechanisms.

Free Research Field

代謝内科学