2015 Fiscal Year Final Research Report
Role of Pref-1 in the ovary as a novel infertility factor
| Project/Area Number |
15K15355
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Keywords | 卵巣 / Pref-1 |
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| Outline of Final Research Achievements |
Previously we found Pref-1 as a novel target gene of SF-1. In this study, we examined expression pattern of Pref-1 in the ovary by using gene expression and immunohistochemistry. The expression pattern of Pref-1 was very similar to those of steroidogenesis related genes such as StAR and CYP11A1, suggesting that Pref-1 works as a member of ovarian steroidogenesis or folliculogenesis. Pref-1 is known as a factor involved in the differentiation of adiposite. In this study, we identified, for the first time, that Pref-1 is also a member of steroidogenesis in the ovary and is involved in follicular development.
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| Free Research Field |
内分泌学
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