2016 Fiscal Year Final Research Report
Crosstalk between GVHD and fungal infection
| Project/Area Number |
15K15358
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | GVHD / Candida / 肺 / Th17 / Dectin-2 / mannan |
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| Outline of Final Research Achievements |
We evaluated mechanistic link between graft-versus-host disease (GVHD) and Candida infection after allogeneic hematopoietic stem cell transplantation (SCT) in mouse models. Injection of alpha-Mannan, a major component of fungal cell wall, or heat-killed Candida albicans accelerated lung GVHD. alpha-Mannan induced donor Th17 differentiation and lung specific chemokine environment in GVHD led to Th17 infiltration to the lung. Such effects of alpha-Mannan on GVHD was dependent on both recipient Dectin-2 and donor IL-17A. These results demonstrate a novel mechanistic link between GVHD and Candida infection following allogeneic SCT.
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| Free Research Field |
血液内科学
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