2016 Fiscal Year Final Research Report
Hematopoietic regulation by five senses: scent
| Project/Area Number |
15K15363
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | かおり / 細胞運命制御 |
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| Outline of Final Research Achievements |
I confirmed mRNA expression of olfactory-specific molecules such as AC3 and Golf in mouse bone marrow, thymus, spleen as well as in cell lines of hematopoietic progenitors and T cells. I also confirmed the protein expression in some of these tissues and cells. G-CSF-induced hematopoietic progenitor mobilization was not altered when an α-pinin was administered together with G-CSF.
We next focused on the in vitro effect of a substance on the cell fate determination in many kinds of cell lines including both hematopoietic and mesenchymal lineage cells. I cannot release the information about this part because I have a plan to apply for a patent.
|
| Free Research Field |
血液内科学
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