2016 Fiscal Year Final Research Report
Elucidation of immuno-pathogenesis of IgG4-related disease by focusing on innate immune responses to intestinal microflora
| Project/Area Number |
15K15370
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Kindai University (2016)
Kyoto University (2015) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | IgG4関連疾患 / 自己免疫性膵炎 / 形質細胞様樹状細胞 |
|---|
| Outline of Final Research Achievements |
We tried to elucidate innate immune responses involved in the development of IgG4-related autoimmune pancreatitis (AIP). To this end, we utilized samples obtained from murine experimental models of AIP and human IgG4-related AIP. In both human and animal studies, we found that AIP-related innate immune responses are characterized by activation of plasmacytoid dendritic cells (pDCs). The development of AIP depends upon both IFN-alpha and IL-33 produced by pDCs. Taken together, these data suggest that activation of pDCs upon sensing of intestinal microflora induces IgG4-related AIP through the production of IFN-alpha and IL-33.
|
| Free Research Field |
消化器免疫学
|
