Analysis of macrophages in Adult onset Still's disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15374
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Yokohama City University
• Principal Investigator: KIRINO Yohei 横浜市立大学, 医学部, 講師 (50468154)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 成人スティル病 / マクロファージ / ヘムオキシゲナーゼ1 / フェリチン

Outline of Final Research Achievements

In the current study, we collected sera from a total of 145 AOSD patients. These AOSD' patients were further divided into active, remission, and relapse groups. Forty-six cases of systemic vasculitis, sepsis, etc. were included as disease controls. We found that serum ferritin and HO-1 levels were significantly higher in active and relapsed AOSD cases, and were reduced by the treatment. Although a significant correlation was found between serum ferritin and HO-1 levels, a discrepancy was found in some cases such as iron-deficiency anemia.ROC analysis identified optimal levels of serum ferritin (>819 ng/ml; sensitivity 76.1% and specificity 73.8%), and serum HO-1 (>30.2 ng/ml; sensitivity 84.8% and specificity 83.3%) that differentiated AOSD from controls. Interestingly, 88.9% of patients with AOSD who relapsed exceeded the cut-off value of serum HO-1, but only 50.0% exceeded serum ferritin , suggesting that serum HO-1 levels may be a convenient indicator of AOSD disease status.

Free Research Field

リウマチ・膠原病