Identification of chitin binding protein(s) and analysis of cellular signal transduction by stimulation of chitin.

2015 Fiscal Year Final Research Report

• Project/Area Number: 15K15377
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Saito Hirohisa 国立研究開発法人国立成育医療研究センター, 研究所, 副所長 (40130166)
• Co-Investigator(Renkei-kenkyūsha): NAKAE SUSUMU 東京大学, 医科学研究所 システムズバイオロジー分野, 准教授 (60450409) ; SUDO KATSUKO 東京医科大学, 動物実験センター, 講師 (50126091) ; MATSUMOTO KENJI 国立研究開発法人国立成育医療研究センター, 研究所 免疫アレルギー・感染研究部, 部長 (60181765) ; NAKAJIMA HIDEKI 国立研究開発法人国立成育医療研究センター, 研究所 マススクリーニング研究室, 研究員 (30450620)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Keywords: アレルギー

Outline of Final Research Achievements

Although it is considered that chitin (a major component of the outer shell of house dust mite) can contribute to the induction of allergic responses, it still remains unclear the mechanism of cellular signal transduction by stimulation of chitin. In this study, we attempted to identify chitin binding proteins, and finally found four chitin-binding proteins. In the future, we will investigate the role of these molecules in development of house dust mite antigen-mediated allergic disorders.

Free Research Field

医歯薬学