Analysis on androgen dependent pelvic muscle formation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15403
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Yamada Gen 和歌山県立医科大学, 先端医学研究所, 教授 (80174712)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: アンドロゲン / 筋肉発生 / 骨盤 / 男性ホルモンレセプター(AR) / 生殖機能 / 生殖器

Outline of Final Research Achievements

The bulbocavernosus (BC) is a sexually dimorphic muscle observed only in males. Androgen signaling plays a vital role in its development. To identify the mechanism of sexual dimorphism during BC development, AR mutation in the adjacent mesenchyme using Sall1 Cre driver mouse was performed, which resulted in defective BC formation. This study suggests that the nonmyocytic AR regulates the formation of myoblasts. Explant culture including Sall1 GFP positive cells responded to the addition of DHT. The culture system is expected to offer vital information for the functions of such mesenchyme in response to androgen.

Free Research Field

発生医学、生殖器形成