2016 Fiscal Year Final Research Report
A Challenge of radio-isotope therapy for atherosclerosis: Development of a radiopharmaceutical to suppress macrophage infiltration
Project/Area Number |
15K15440
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Hokkaido University |
Principal Investigator |
KUGE YUJI 北海道大学, アイソトープ総合センター, 教授 (70321958)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 放射線 / 核医学 / RI内用療法 / 動脈硬化 / 組織因子 |
Outline of Final Research Achievements |
In the medication of atherosclerosis, early treatment of vulnerable plaque which plays a pivotal role for ischemic diseases such as myocardial infarction, is necessary. Thus, it is desired to develop an effective treatment method for this systemic disease. Tissue factor (TF) is a well-known factor which is highly expressed in the macrophages infiltrated in atherosclerotic plaques and is significantly related to the plaque rupture and following thrombus formation. Thus, aiming to achieve a highly selective and complete treatment of atherosclerotic lesions, especially vulnerable plaques, we conducted basic experiments to developed a novel radiopharmaceutical targeting TF for radio-isotope therapy (internal radiation therapy) of atherosclerosis.
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Free Research Field |
放射線科学
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