Evaluation of arrhythmogenesis in patients with cardiac sarcoidosis using PET-MRI fusion images

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15441
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Tamaki Nagara 北海道大学, 医学研究科, 特任教授 (30171888)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 心サルコイドーシス / PET-MRI

Outline of Final Research Achievements

We established a method for semi-automatic and quantitative measurement of activity of glucose metabolism in the myocardial inflammation using FDG-PET. Evaluation of steroid treatment effect by quantitative metabolic volume (MV) revealed that 1 month of steroid treatment markedly reduced myocardial inflammation, but cardiac function improvement was not observed. Patients presenting with the acute phase of AV block are related to FDG accumulation rather than MRI delayed contrast images and may be associated with the activity of inflammation. Detailed assessment between changes in electrocardiogram findings after treatment and image inspection including FDG PET, MRI and sympathetic function is required in the future.

Free Research Field

核医学