Exploratory Research for a non-invasive functional organ regeneration

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15466
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Shimokawa Takashi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線障害治療研究部, 主任研究員(定常) (20608137)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 粒子線 / 再生

Outline of Final Research Achievements

This study aims evaluation of biological reactions to establishing a non-invasive organ regeneration technology by using a particle beam irradiation, which has already been used as a cancer treatment device. I conducted the analysis using the following three experimental systems i) in vitro 3D culture system using collagen sponge, ii) in vivo experiment system using planaria and iii) in vivo experiment system using mouse models.
The results of the project showed that carbon ion beam, a type of particle beam, can destroy the target site particularly in normal tissues. Furthermore, it is possible to obtain important basic data for the future use of particle beams for regenerative medicine, such as the difference in the attracting effect to the injured site by irradiation between cancer cells and normal cells.

Free Research Field

粒子線治療生物学