Research on the novel risk of breast cancer focusing of the regulation of endo/exogenous substances in mammary glands

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15470
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Toyoda Yu 東京大学, 医学部附属病院, 特任助教 (80650340)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 乳がん / トランスポーター / メタボローム解析

Outline of Final Research Achievements

Recently, based on an epidemiological study focusing on the patients with breast cancer in Japan, it has been pointed out that the ABCC11 wild type (WT) could be associated with the risk of breast cancer. However, it has not been well understood whether ABCC11 WT really contributes to the breast cancer risk. The aim of this study was to clear the latent relationship. Since in vivo and in vitro models are arranged as well as metabolomics technique, key molecules that are substrates for ABCC11 and could affect the nature of mammary gland should be determined in the near future.

Free Research Field

医歯薬学