Establishment of a method for immunostimulation to compensate gene polymorphism-associated deterioration of NK cell function

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15476
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Hiroshima University
• Principal Investigator: Hideki Ohdan 広島大学, 医歯薬保健学研究院(医), 教授 (10363061)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 免疫賦活療法 / NK細胞 / 個別化医療 / 癌免疫 / 自然免疫

Outline of Final Research Achievements

The aim of this study is to establish a method for immunostimulation to compensate gene polymorphism-associated deterioration of NK cell function. In mouse models, we found that heat shock protein (HSP)70 inducer enhance the expression of TRAIL on live NK cells. We investigated the effects of epigenetic drugs on immunogenicity of neoplastic cells and function of NK cells by use of clinical specimens and human lymphocytes. In addition, we found that ex vivo licensing NK cells developed from hematopoietic stem cells for adoptive immunotherapy was feasible by cultivating them with HLA class I-KIR matched fibroblasts.

Free Research Field

消化器外科、移植外科