Exploring the role of methylation and hydroxymethylation in Hereditary Breast and Ovarian Cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15478
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: 独立行政法人国立病院機構(東京医療センター臨床研究センター)
• Principal Investigator: Yamazawa Kazuki 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 医師 (10338113)
• Co-Investigator(Kenkyū-buntansha): 松永 達雄 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚平衡覚研究部, 部長 (90245580)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 遺伝性乳癌卵巣癌 / 遺伝性腫瘍 / メチル化 / ヒドロキシメチル化

Outline of Final Research Achievements

The novel method to analyze the distribution of methylation/hydroxymethylation in genomic DNA has been developed. Using this method, we first reported the hydroxymethylation status in congenital human imprinting disorders. Next, we have tried to analyze the blood and tumor samples derived from the hereditary tumor syndromes; however, a limited number of tumor samples and denaturation of DNA have created much difficulties in performing the analysis. It has taken more time than expected to re-collect and re-analyze human tumor samples, thus the investigation has yet to be completed. We are still conducting the analysis.

Free Research Field

エピジェネティクス