2016 Fiscal Year Final Research Report
Regulation of metabolism and inflammation through hepatic vagus nerve system in steatohepatitis
Project/Area Number |
15K15495
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Kyoto University |
Principal Investigator |
Taura Kojiro 京都大学, 医学研究科, 講師 (80378629)
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Research Collaborator |
NISHIO Takahiro 京都大学, 大学院医学研究科, 大学院生
Yamamoto Gen 京都大学, 大学院医学研究科, 大学院生
TANABE Kazutaka 京都大学, 大学院医学研究科, 大学院生
OKUDA Yukihiro 京都大学, 大学院医学研究科, 大学院生
IKENO Yoshinobu 京都大学, 大学院医学研究科, 大学院生
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | NASH / 迷走神経 / クッパー細胞 / ニコチン性アセチルコリン受容体α7 |
Outline of Final Research Achievements |
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by steatosis with progressive inflammation. Kupffer cells, which are liver-resident macrophages, play a central role in promoting hepatic inflammation by innate immune responses in NASH. The efferent vagus nerve signaling is known to have an anti-inflammatory effect on immune cells via the α7 nicotinic acetylcholine receptor (α7nAChR) pathway. This study demonstrated that the hepatic vagus nerve plays a key role in regulating the inflammatory response in Kupffer cells via the α7nAChR pathway and eventually contributed to the suppression of NASH progression, by using mouse experimental model of NASH.
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Free Research Field |
肝臓外科 肝線維化 肝移植
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