Callenging Biotube growth ~From fabrication to verification of a juvenile beagle model~

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15513
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Furukoshi Maya 国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員 (20739247)
• Research Collaborator: NAKAYAMA Yasuhide ; TAKAMIZAWA Keiichi ; IWAI Ryousuke ; MORIWAKI Takeshi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 成長性 / 再生医療 / Biotube / 人工血管 / 小児血管外科

Outline of Final Research Achievements

This study revealed that growth ability of “Biotube” vascular grafts which can be made in a living body. Biotubes are made by in body tissue architecture technology (IBTA), which is one of regenerative medical technology. Only by embedding a mold into subcutaneous pouches of a living body for 2 months, an autologous implantable tissue with desired shape and size can be obtained.
When a Biotube implanted into native arteries, it can engraft to native tissues and then regenerate to three-layered vascular construction within few months. In this study, we confirmed that after implantation of Biotubes into common carotid arteries of juvenile beagles, their diameter and length increased according to the growth of native arteries. This results suggested that Biotubes have growth potential in a living body.

Free Research Field

心臓血管外科