Multilateral investigation on various antibodies aiming at realization of ABO incompatible and/or crossmatch positive lung transplantation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15516
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Kyoto University
• Principal Investigator: CHEN Fengshi 京都大学, 医学研究科, 講師 (00452334)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: HLA抗体 / 肺移植

Outline of Final Research Achievements

Recently, the importance of donor-specific anti-HLA antibodies (DSAs) has been pointed out in lung transplantation. We investigated various characteristics of DSAs in living-donor lobar lung transplantation (LDLLT) and cadaveric lung transplantation (CLT). Anti-HLA antibodies have been prospectively screened periodically in 134 patients undergoing lung transplantation. Anti-HLA antibodies were screened in 64 patients with LDLLT and 70 patients with CLT before and after lung transplantation. Postoperatively, 17 patients (13%) had de novo DSAs. There were 3 patients in LDLLT (5%) and 14 patients in CLT (20%, p=0.001). In LDLLT, DSAs vanished in 1 out of 3 patients, while, in CLT, DSAs were detected within 3 months postoperatively in 10 out of 14 patients (p=0.12). We confirmed that de novo DSAs were detected less frequently in LDLLT than in CLT.
Furthermore, we investigated chimerism of the lungs using injured lungs after hematopoieticstem cell transplantation.

Free Research Field

呼吸器外科