Establishment of a specific therapy for lung cancer stem cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15519
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Abe Jiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (10573686)
• Co-Investigator(Kenkyū-buntansha): 佐藤 賢一 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺癌

Outline of Final Research Achievements

To evaluate the role of cancer stem cells in lung cancer, we developed patient-derived xenografts (PDXs) on NOG mice. We sorted the cells from lung squamous cell carcionoma PDXs by known cell surface markers and xenograft into NOG mice. We found that high expression of a molecule XX possess high tumorigenicity. By XX knock down using siRNA, the proliferation capacity was completely inhibited. Apoptotic cells were increased and migration capability was attenuated by XX knock down. These results suggested that XX may be a good therapeutic target for lung squamous cell carcionoma.

Free Research Field

呼吸器外科学