angiogenic therapy for cerebral infarction with anti^sense homology derived peptide targeting angiogenic factor

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15523
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: TAKANO SHINGO 筑波大学, 附属病院, 病院講師 (50292553)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アンチセンスホモロイーボックス / ペプチド療法 / FGF2 / 脳梗塞 / 内皮細胞

Outline of Final Research Achievements

Anti-sense homology box (AHB) is composed of sense peptide complemented with anti-sense peptide and distributed physiologically within the molecule. Peptide synthesized by amino acid complemental to AHB has been suggested to have some physiological function to its target protein. We made a peptide targeting to FGFR derived AHB. A peptide located in extracellular domain of FGFR showed a prominent endothelial cell proliferative activity. Its proliferative action was disappeared by amino acid exchanging peptide and siRNA for FGFR. This peptide has angiogenic activity and is available for therapy of cerebral infarction.

Free Research Field

脳神経外科