Challenging study of molecular mechanisms in pineal parenchymal tumor

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15526
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: Miyamoto Susumu 京都大学, 医学研究科, 教授 (70239440)
• Co-Investigator(Renkei-kenkyūsha): Matsuda Fumihiko 京都大学, 医学研究科, 教授 (50212220)
• Research Collaborator: Tsuruyama Tatsuaki 京都大学, 医学研究科, 准教授 (60437332) ; kuyama hiroki ; Fujimoto Ko-ichi ; Liu Bin
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 松果体実質性腫瘍 / ｐineal parenchymal tumor / 分子メカニズム / molecular mechanism / pinealocyte / 悪性転化

Outline of Final Research Achievements

Pineal parenchymal tumor is a rare tumor deriving from pinealocyte and molecular mechanisms of its oncogenesis and malignant transformation remain unclear. In this study, we have analyzed molecular mechanism in pineal parenchymal tumor using formalin fixed paraffin embedded (FFPE) tumors. Expression of chromogranin A could be a prognostic maker better than thatt of neurofilament. Expression of somatostatin type2 (SSTR2) is increased, but did not have significant relationship with clinical result, other neuronal maker and malignancy.

Free Research Field

脳神経外科