2016 Fiscal Year Final Research Report
Elucidation of molecular mechanism underlying chondrocyte dedifferentiation
Project/Area Number |
15K15539
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Shinomura Tamayuki 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (70206118)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 軟骨細胞 / 脱分化 |
Outline of Final Research Achievements |
For both basic research and clinical applications, it is very important to prevent dedifferentiation of chondrocytes. Therefore, in this study I have performed a comprehensive analysis of the molecular mechanisms that control the dedifferentiation of chondrocytes using Swarm rat chondrosarcoma chondrocytes. Although the mechanisms are still unclear, I have established a new experimental system to specifically and efficiently induce the chondrocyte dedifferentiation by a retrovirus vector. So, by determining the retrovirus insertion sites, we will be able to elucidate the molecular mechanism of the dedifferentiation.
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Free Research Field |
生化学
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