Regulation of muscle satellite cells differentiation via Rp58

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15544
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ASAHARA Hiroshi 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70294460)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨格筋 / サテライト細胞 / DNAメチル化 / 筋再生

Outline of Final Research Achievements

Muscle, a power source in our musculoskeletal function, has long been studied in medicine and biology for its regeneration mechanism by tissue stem cells and transcriptional control system starting with MyoD. We identified Rp 58 as a transcription factor essential for muscle differentiation and showed that this could be responsible for muscle differentiation control in conjunction with DNA methylation. The results of this research are expected to contribute to muscle diseases and regenerative medicine.

Free Research Field

分子生物学、発生・再生医学、整形外科学