Identification of bone derived brain function regulating factor through bone-brain cross talk.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15545
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ochi Hiroki 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (30582283)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 骨代謝 / 成長ホルモン / 臓器連関

Outline of Final Research Achievements

The purpose of this study was to clarify the regulatory mechanism of the bone derived brain regulating factor. Firstly, we generated the bone specific membrane protein deficient (CKO) mice and analyzed. CKO mice showed dwarfism via low serum GH and IGF-1, and then low bone mass caused by decrease of osteoblast differentiation. Furthermore, matured osteoblast derived factors inhibited the GH expression on a GH3 pituitary cell line. These findings in this study indicates that bone regulates GH secretion in pituitary. We are now trying to clarify the molecular mechanism on the regulation of GH secretion by bone-derived factors.

Free Research Field

骨代謝