Maternal behavior impairments in ASIC1a knockout female mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15554
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya City University
• Principal Investigator: Wakabayashi Kenjiro 名古屋市立大学, 大学院医学研究科, 助教 (20418867)
• Co-Investigator(Kenkyū-buntansha): 和田 郁雄 名古屋市立大学, 大学院医学研究科, 教授 (70182970) ; 佐久間 英輔 名古屋市立大学, 大学院医学研究科, 講師 (90295585) ; 村上 里奈 名古屋市立大学, 大学院医学研究科, 助教 (10535818) ; 青山 公紀 名古屋市立大学, 大学院医学研究科, 助教 (10597818)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 育児障害 / 酸感受性イオンチャンネル / ドーパミン / トランスポーター

Outline of Final Research Achievements

The acid-sensing ion channel (ASIC) family is a major branch of the mechanosensory degenerin/epithelial Na+ channel superfamily. Here, we report that acid-sensing ion channels (ASICs) type 1a knockout (KO) female mice exhibit the impairment in maternal behavior. The ASIC 1a KO female mice also show the downregulation of the dopamine transporter (DAT). While the function of these interactions is not well understood, it might be possible that the interactions between coexisting plural channels and transporters play some crucial roles to maintain the synaptic action. In this paper, we propose that the ASIC 1a KO female mice express the impairment in maternal behavior from the downregulation of the DAT.

Free Research Field

小児整形外科