Development of new OA therapy targeting HIF-1a

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15555
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Kubo Toshikazu 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20178031)
• Co-Investigator(Kenkyū-buntansha): 新井 祐志 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (50347449) ; 中川 周士 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30643382)
• Co-Investigator(Renkei-kenkyūsha): Mazda Osam 京都府立医科大学, 医学研究科, 教授 (00271164)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 関節軟骨 / 低酸素 / メカニカルストレス

Outline of Final Research Achievements

Articular cartilage is physiologically in a hypoxic condition, and HIF-1α is important for chondrocyte survival, differentiation, and metabolism. We tried to force rats to run on treadmill and evaluate that the production of HIF-1, 2α in articular cartilage were changed by running speed. Furthermore, by analyzing the mechanical stress application mechanism in hypoxic condition in vitro, We expected that genes different from regulating in normoxic condition may regulate cartilage metabolism in hypoxic condition.

Free Research Field

軟骨代謝