The regulation of osteocyte function and mechanosignaling via light stimulus

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15558
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Osaka Dental University
• Principal Investigator: NOTOMI Takuya 大阪歯科大学, 歯学部, 講師 (70542249)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 骨代謝 / 骨細胞 / 光遺伝学

Outline of Final Research Achievements

Age-related bone diseases such as osteoporosis are serious problem in an aged society. To prevent these bone diseases, we have done the study of relationships between the changes in membrane potential and bone remodeling. To investigate the relationships between mechanosignaling and the changes in membrane potential, the light-gated ion channels and pump were transfected into osteocyte and their cells were transplanted to calvariae bone. After invivoloading on bone, invivo loading with light stimulus increased bone formation compared to control. In summary, our results indicate that the changes in membrane potential affects the response of bone mechanosignaling.

Free Research Field

骨生物学