Search for biodegradable scaffolding materials of bones and ligaments in growth and medicine and creation of fusion proteins

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15559
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: National Center for Child Health and Development
• Principal Investigator: TAKAYAMA SHINICHIRO 国立研究開発法人国立成育医療研究センター, 臓器・運動器病態外科部, 部長 (40138045)
• Co-Investigator(Kenkyū-buntansha): 梅澤 明弘 国立研究開発法人国立成育医療研究センター, 再生医療センター, 副所長/再生医療センター長 (70213486)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 小児運動器学 / キメラタンパク質 / 再生医療 / 生分解性材料

Outline of Final Research Achievements

By using mesenchymal cells, regenerative induction therapy that activates functions related to target tissues is considered to be one of regenerative medicine. Mesenchymal cells have both high proliferative ability, self-replicating ability and partial totipotency properties, and are also attracting attention as a transplantation device for cell replacement therapy. Bone disease can occur to anyone in daily life. In this study, a basic experiment as a scaffold material using a recombinant protein was carried out and verification of its effectiveness was completed.

Free Research Field

医歯薬学