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2017 Fiscal Year Final Research Report

The mechanism of propofol infusion syndrome and the prevention effects by canrnitine

Research Project

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Project/Area Number 15K15573
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionKagoshima University

Principal Investigator

Moriyama Takahiro  鹿児島大学, 医歯学域附属病院, 講師 (20593651)

Co-Investigator(Kenkyū-buntansha) 堀内 正久  鹿児島大学, 医歯学域医学系, 教授 (50264403)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsプロポフォール / L-カルニチン / 遊離脂肪酸
Outline of Final Research Achievements

FFA increased in Group P and gradually decreased in Group P + C. There were significant differences between the two groups at the three-hour point (Group P; 331.2 ± 64.5 vs. Group P + C; 199 ± 73.6 ). Glucose decreased in groups (Group P; 53.8 ±16.6 mg/dL vs. Group P + C; 88 ± 11.3 mg/dL) at the three-hour point. Amino acid concentrations were higher in Group P + C compared with Group P after experiments; alanine and glutamine increased significantly. β-hydroxybutyric acid increased significantly in Group P + C, and intrahepatic triglyceride decreased in Group P + C. Dependency on fatty acid metabolism significantly decreased with propofol only; addition of L-carnitine prevented these effects.
Conclusions Propofol impaired mitochondrial fatty acid metabolism, which was compensated mainly by a switch to glucose metabolism and partially by amino acid metabolism. Addition of L-carnitine may improve this imbalance of energy metabolism.

Free Research Field

麻酔

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Published: 2019-03-29  

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