Development of novel real time monitaring for fetal brain metabolism using diffuse reflectance

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15595
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: Fujii Tomoyuki 東京大学, 医学部附属病院, 教授 (40209010)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 低酸素虚血性脳障害 / 拡散反射分光 / ラットモデル / 分娩

Outline of Final Research Achievements

Hypoxic ischemic encephalopathy (HIE) during labor is one ofthe major causes for cerebral palsy. This study aimed to identify intrinsic optical signals to detect tissue deterioration prior to the occurrence of HIE during labor using a rat neonate model. In the model, rat neonates underwent left carotid artery ligation followed by an exposure to 8% oxygen. Real-time monitoring for the rat neonate were carried out and the optica data on diffuse reflectance were collected to quantify total hemoglobin, deoxy-Hb concentration and scattering amplitude signal. Rapid reduction of scattering amplitude signal was detected in the hypoxic exposure. This alteration was reflected brain water content caused by hypoxic exposure. This study suggests that scattering amplitude can be a candidate of optical parameter to predict brain tissue deterioration triggered by hypoxia during labor.

Free Research Field

周産期医学