Roles of uterine hypoxia inducible factor in embryo implantation

2015 Fiscal Year Final Research Report

• Project/Area Number: 15K15596
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: Hirota Yasushi 東京大学, 医学部附属病院, 講師 (40598653)
• Co-Investigator(Kenkyū-buntansha): FUJITA Tomoko 東京大学, 医学部附属病院, 特別研究員 (60375441)
• Research Collaborator: HARAGUCHI Hirofumi 東京大学, 大学院医学系研究科, 大学院生 ; MATSUMOTO Leona 東京大学, 大学院医学系研究科, 大学院生 ; EGASHIRA Mahiro 東京大学, 農学生命科学研究科, 大学院生 ; MATSUO Mitsunori 東京大学, 大学院医学系研究科, 大学院生 ; HIRAOKA Takehiro 東京大学, 大学院医学系研究科, 大学院生
• Project Period (FY): 2015-04-01 – 2016-03-31
• Keywords: 着床 / 低酸素 / HIF / マウスモデル / 子宮 / 子宮内膜 / HIF2α / 脱落膜化

Outline of Final Research Achievements

Roles of uterine hypoxia inducible factor (HIF) in early pregnancy remain unknown. In this study, we found that mice with conditional deletion of uterine Hif2a are infertile, and have the dislocation of implantation sites and defective decidualization. We also found that supplementation of progesterone markedly improve decidualization but can not recover full pregnancy in Hif2a conditional knockout mice. These findings suggest that HIF in the periimplantation uterus may support successful implantation and decidualization.

Free Research Field

産婦人科学