Study on the mechanisms of placental aging

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15601
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Shinshu University
• Principal Investigator: SHIOZAWA TANRI 信州大学, 学術研究院医学系, 教授 (20235493)
• Co-Investigator(Kenkyū-buntansha): 樋口 正太郎 信州大学, 医学部附属病院, 助教(診療) (50750098) ; 大平 哲史 信州大学, 学術研究院医学系(医学部附属病院), 講師 (90397315)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 胎盤老化 / 細胞老化 / サイトトロフォブラスト / シンシチオトロフォブラスト / 合胞体化 / p21 / p16

Outline of Final Research Achievements

We studied the placental aging from the point of view of cell senescence (CS). We studied the placental aging from the point of view of cell senescence (CS). In the placental villi from the 1st to 3rd trimester of pregnancy, the ratio of cytotrophoblast (CT) positively expressing CS markers such as β-gal, p16, p21, PML was consistently high. The nuclei of syncytiotrophoblast (ST) expressing CS markers have increased and the number of CTs decreased in the 3rd trimester. Expression of the CS markers such as p16 and p21 was enhanced in the syncytial process of BeWo cells induced by the forskolin stimulation, suggesting that CS occurred in the syncytial process of CT. It was considered that the placental dysfunction might be induced by CS of ST that was possibly associated with the depletion of CT due to the syncytial formation.

Free Research Field

産婦人科学　産科学