roles of fibroblats in endometriosis for tumor transformation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15611
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Juntendo University
• Principal Investigator: KITADE Mari 順天堂大学, 医学部, 教授 (20266026)
• Co-Investigator(Kenkyū-buntansha): 折茂 彰 順天堂大学, 医学(系)研究科(研究院), 准教授 (70275866)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 子宮内膜症 / チョコレート嚢腫 / 疾患マウスモデル / 線維芽細胞 / 癌化

Outline of Final Research Achievements

Endometriosis is a progressive disease that causes infertility and malignant transformation. In this study, we developed a mouse model for endometriosis by implantation of the affected tissues surgically dissected from totally 8 patients into immunodeficient mice. Sarcoma-like tumors were emerged in two out of eight patients.

Free Research Field

婦人科