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2017 Fiscal Year Final Research Report

Development of sublingual immunotherapy with Transgenic rice seeds in patients with cedar pollinosisi

Research Project

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Project/Area Number 15K15618
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionShimane University

Principal Investigator

hideyuki kawauchi  島根大学, 医学部, 教授 (50161279)

Co-Investigator(Kenkyū-buntansha) 森倉 一朗  島根大学, 医学部, 講師 (00362939)
飯笹 久  島根大学, 医学部, 准教授 (80306662)
青井 典明  島根大学, 医学部, 准教授 (80452556)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsアレルギー性鼻炎 / スギ花粉症 / 舌下免疫療法 / 経口免疫療法 / 調節性T細胞 / スギ花粉症治療米 / protein body / 免疫学的寛容
Outline of Final Research Achievements

we examined whether mucosal route of immunizations with Transgenic rice(Tg-rice) containing hyporeactive whole T-cell epitopes of Cryj1 and Cryj2, can actually attenuate nasalsymptoms in a murine model of cedar pollinosis. As results, sublingual administration or natural feeding of Tg-rice was able to attenuates nasal symptoms at the induction and eliciting phase as well. Furthermore eosinophil infiltration was less in those mice, and antigen-specific Th2 responses(I-5, IL-13 production) of cervical lymph node lymphocytes was significantly downregulated with regulatory T cell induction. Purified protein body fraction more efficiently attenuated nasal symptoms with less amount rather than transgenic rice itself.

Free Research Field

耳鼻咽喉科学

URL: 

Published: 2019-03-29  

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