2017 Fiscal Year Final Research Report
Development of sublingual immunotherapy with Transgenic rice seeds in patients with cedar pollinosisi
| Project/Area Number |
15K15618
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
森倉 一朗 島根大学, 医学部, 講師 (00362939)
飯笹 久 島根大学, 医学部, 准教授 (80306662)
青井 典明 島根大学, 医学部, 准教授 (80452556)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | アレルギー性鼻炎 / スギ花粉症 / 舌下免疫療法 / 経口免疫療法 / 調節性T細胞 / スギ花粉症治療米 / protein body / 免疫学的寛容 |
|---|
| Outline of Final Research Achievements |
we examined whether mucosal route of immunizations with Transgenic rice(Tg-rice) containing hyporeactive whole T-cell epitopes of Cryj1 and Cryj2, can actually attenuate nasalsymptoms in a murine model of cedar pollinosis. As results, sublingual administration or natural feeding of Tg-rice was able to attenuates nasal symptoms at the induction and eliciting phase as well. Furthermore eosinophil infiltration was less in those mice, and antigen-specific Th2 responses(I-5, IL-13 production) of cervical lymph node lymphocytes was significantly downregulated with regulatory T cell induction. Purified protein body fraction more efficiently attenuated nasal symptoms with less amount rather than transgenic rice itself.
|
| Free Research Field |
耳鼻咽喉科学
|
