New clinical evidence for glaucoma surgery based on immunology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15630
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: University of Fukui
• Principal Investigator: Inatani Masaru 福井大学, 学術研究院医学系部門, 教授 (40335245)
• Co-Investigator(Renkei-kenkyūsha): TAKAMURA Yoshihiro 福井大学, 学術研究院医学系部門, 准教授 (00283193) ; TAKIHARA Yuji 福井大学, 医学部附属病院, 助教 (50640140) ; MIYAKE Seiji 福井大学, 学術研究院医学系部門, 助教 (50572765) ; MATSUMURA Takehiro 福井大学, 学術研究院医学系部門, 助教 (40529369)
• Research Collaborator: ARIMURA Shogo ; GOZAWA Makoto ; IWASAKI Kentaro
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 眼免疫学 / 緑内障

Outline of Final Research Achievements

Filtering surgery allows traffic between inside the eye and outside the eye, then, the blood-aqueous humor barrier breaks down. Therefore, we hypothesize that immune reaction would occur, then, further filtration surgery should result in surgical failure. Our studies revealed the following data. When a patient who had undergone successful trabeculectomy, the surgical outcome of the second trabeculectomy in the other eye is adversely affected by longer interval between the first and second trabeculectomies. The formation of the filtering bleb by tube shunt surgery is adversely affected by repeated intraocular surgeries.

Free Research Field

緑内障