Effects of genomic damage by chemo-radiation therapy during childhood for secondary malignancy and genetic inheritance

2015 Fiscal Year Final Research Report

• Project/Area Number: 15K15644
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatric surgery
• Research Institution: Hiroshima University
• Principal Investigator: HIYAMA EISO 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
• Co-Investigator(Kenkyū-buntansha): KURIHARA SHO 広島大学, 大学病院, 医科診療医 (40724894)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Keywords: ゲノム / 放射線 / がん / 遺伝学 / 遺伝子

Outline of Final Research Achievements

Genomic sequencing analysis was performed in the 15 groups consisting of the survivor who had undergone the treatment for childhood cancer after 1980, its partner, and descendant. Among 6 survivors whose tumors had been advanced of stage, exome analysis revealed 2, 9, 12, 16, 32, and 84 mutations occurred after treatment, respectively. Among 4 survivors including 2 survivors with secondary malignancy, whole genome sequencing revealed 126、87、73, 198 mutations occurred after treatment. The genomic analysis of 3 descendants using exome analysis, 3 of 84, 1 of 12, and 0 of 34 mutations were suspected to be inherited, respectively. The exome analysis of 4 cases with secondary malignancies showed no common mutations nor mutation signatures.

Free Research Field

小児腫瘍学、小児外科学