Pathophysiology of coagulation and fibrinolysis at an early phase of trauma.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15658
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Hokkaido University
• Principal Investigator: Gando Satoshi 北海道大学, 医学研究院, 特任教授 (30125306)
• Co-Investigator(Renkei-kenkyūsha): SAWAMURA Atsushi 北海道大学, 大学院医学研究院, 特任准教授 (00241448) ; HAYAKAWA Mineji 北海道大学, 大学院医学研究院, 講師 (10374282) ; YANAGIDA Yuichiro 福岡市民病院, 救急科, 医員 (20455645) ; WADA Takeshi 北海道大学, 大学院医学研究院, 助教 (30455646) ; MIYAMOTO Daisuke 洞爺協会病院, 内科, 内科部長 (90750696)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 外傷 / 凝固線溶系 / 播種性血管内症候群（DIC

Outline of Final Research Achievements

To elucidate the mechanisms of trauma-induced coagulopathy, prospective and retrospective studies were performed. We demonstrated that trauma itself induces changes in coagulation and fibrinolysis, which consists of activation of coagulation (thrombin generation), insufficient anticoagulation systems (TFPI, antithrombin, protein C and thrombomodulin), and inhibition of fibrinolysis by PAI-1. The conditions are coincided with the pathophysiology of disseminated intravascular coagulation (DIC). These evidences were also confirmed by experimental studies using Noble-Collip Drum rat trauma models. Base on the results, we have published several original studies and review articles including one systematic review. To confirm these phenomenon, we, have conducted prospective multicenter study recruiting 108 institutes in Japan. The study has now completed and is waiting the publication of the obtained results in the English journal.

Free Research Field

医歯薬学