2016 Fiscal Year Final Research Report
C4d deposition on the surface of RBCs may interfere with their function in severe patients
Project/Area Number |
15K15672
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Emergency medicine
|
Research Institution | Kansai Medical University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Keywords | 赤血球 / 補体 / 重症患者 |
Outline of Final Research Achievements |
We measured C4d (one of the factor of compliment) deposition on the surface of RBCs (Red Blood Cells) with flow cytometry in the patients who were transferred to Trauma and Critical Care Center and assessed the relation in the severity of the patients and the amount of the deposition. We used the APACHEII score and SOFA score as the patients’ severity. There is the significant deference in the patients group and normal healthy donors (n=25 vs 10;p<0.01). There is no correlation in C4d deposition on the surface of RBCs and the severity sores. Severe patients have more C4d deposition of their RBCs surface, but no correlation in C4d deposition and severity score in existence. We may assess the immune reaction of the severe patients by the measurement of the complement deposition of patients’ RBCs surface.
|
Free Research Field |
救急医学
|