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2016 Fiscal Year Final Research Report

Analysis of Porphyromonas gingivalis-induced neuroinflammation by multi-photon imaging of microglia dynamics

Research Project

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Project/Area Number 15K15684
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionKyushu University

Principal Investigator

Nakanishi Hiroshi  九州大学, 歯学研究院, 教授 (20155774)

Research Collaborator TAKAYAMA Fumiko  
Project Period (FY) 2015-04-01 – 2017-03-31
Keywordsジンジバリス菌 / ミクログリア / 生体蛍光イメージング / 突起伸展 / P2Y6受容体
Outline of Final Research Achievements

In the present study, we have first shown that cortical microglia extend their processes towards focally injected Porphyromonas gingivalis (P. gingivalis). The focally injected P. gingivalis-induced microglial process extension was significantly increased during the light (sleeping) phase than the dark (waking) phase. In contrast, focally injected ATP-induced microglial process extension was significantly increased during the dark phase than the light phase. Furthermore, in contrast to P2Y12 receptor-mediated mechanism of ATP-induced microglial process extension, P. gingivalis-mediated microglial process extension was mediated by P2Y6 receptors. Therefore, P. gingivalis infiltrated in the brain parenchyma may induce the secretion of UDP from microglia at the site of infiltration, UDP, in turn, induces the process extension of neighboring microglia.

Free Research Field

神経薬理学

URL: 

Published: 2018-03-22  

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