2017 Fiscal Year Final Research Report
High-frequency ultrasound diagnostic imaging system to detect niche formation in the lymph nodes in a pre-metastatic phase
Project/Area Number |
15K15690
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
森 士朗 東北大学, 大学病院, 講師 (80230069)
飯久保 正弘 東北大学, 歯学研究科, 講師 (80302157)
小嶋 郁穂 東北大学, 歯学研究科, 助教 (80447169)
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Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
ITO Koichi 東北大学, 情報科学研究科, 助教 (70400299)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | リンパ節転移 / マウスモデル / 超音波 / ナノバブル / マイクロCT |
Outline of Final Research Achievements |
To develop an image analysis system to detect niche formation leading to lymph node (LN) metastasis formation, changes in vascular architecture in the process of LN metastasis formation were analyzed using contrast micro CT imaging and contrast high frequency ultrasound imaging. In the present study, tumor cells were inoculated into the subiliac LN (SiLN) of LN-swollen mouse, MXH10/Mo/lpr, and then metastasis formation process in the proper axillary LN located downstream of SiLN in mouse lymph network was analyzed. The results showed that, in the early stage of LN metastasis, blood vessel density in the LN prior to LN size change was increased. However, angiogenesis in the LN at the early stage of LN metastasis could not be confirmed.
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Free Research Field |
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