Development of a novel mouse model that recapitulates bone invasion of oral cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15694
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Osaka University
• Principal Investigator: Hata Kenji 大阪大学, 歯学研究科, 准教授 (80444496)
• Co-Investigator(Renkei-kenkyūsha): YONEDA Toshiyuki 大阪大学, 大学院歯学研究科, 招へい教員 (80142313)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 口腔がん / 骨浸潤

Outline of Final Research Achievements

Oral squamous cell carcinoma frequently invade the bone of mandible and maxilla and the bone invasion of oral cancer is a critical event that determines the patient poor prognosis. However, molecular mechanisms which regulate bone invasion are not fully understood. Here, we have established novel mouse model which recapitulates the bone invasion of oral squamous cell carcinoma. This model enables the dynamic imaging of bone invasion with high resolution. This mouse model will be a useful tool to understand the mechanism underlying bone invasion and contribute to the development therapeutic reagent for the treatment of bone invasion.

Free Research Field

口腔生化学