A way to molecular targetting preventive medicine:Suppression of lung metastasis of cancer by BRAK gene

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15697
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kanagawa Dental College
• Principal Investigator: Hata Ryu-Ichiro 神奈川歯科大学, 大学院歯学研究科, 特任教授 (10014276)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: がん抑制法 / 癌抑制性ケモカイン / 分子標的予防医学

Outline of Final Research Achievements

The main cause of Japanese death by cancer is due to the recurrence and metastasis. We have previously reported that the rate of carcinogenesis, the growth of tumor transplants and metastasis in CXCL14 over-expressed transgenic (Tg) mouse were significantly lower compared with that for isogenic wild type C57BL/6 (Wt) mice. Here we investigated suppression mechanisms of metastasis by CXCL14 using the pulmonary metastasis system of the malignant melanoma cell and the cell culture system. It was confirmed that anticancer drugs such as cetuximab and gefitinib stimulated expression of BRAK and this is essential for tumor growth suppression.

Free Research Field

がん抑制法