2016 Fiscal Year Final Research Report
Identification of tumor vascular miRNA and application to cancer diagnosis and therapy
| Project/Area Number |
15K15726
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | がん / 腫瘍血管 / miRNA |
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| Outline of Final Research Achievements |
In this study, we have tried to identify miRNAs which are involved in tumor vessel abnormality and to evaluate their roles in tumor invasion and metastasis, in order to develop novel cancer diagnostics and therapy. Endothelial cells were treated by cancer-derived exosome. Several miRNAs were upregulated and their function were analyzed. Using miRNA database, the target gene of these miRNAs were picked up and the involvement of these target molecule in tumor vessel abnormality were addressed.
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| Free Research Field |
口腔外科学
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