Identification of the molecular network regulating movement of Hedgehog proteins on cell surface during skeletal development

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15732
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: Ohba Shinsuke 東京大学, 大学院医学系研究科(医学部), 准教授 (20466733)
• Co-Investigator(Kenkyū-buntansha): 鄭 雄一 東京大学, 大学院工学系研究科(工学部), 教授 (30345053)
• Research Collaborator: HOJO Hironori ; YAMAKAWA Akira ; ICHSAN Mochammad
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 発生・分化

Outline of Final Research Achievements

This study was aimed to understand the mechanism underlying the secretion and release of Hedgehog (Hh) proteins during mammalian skeletal development in an integrative manner. Mutant mice of genes that were involved in the secretion and cell surface regulation of Hh were analyzed. In addition, a new finding on Ihh-expressing cells are being obtained by integrative approach of mouse genetics and molecular biology. These findings will lead to integrative understanding of the secretion and cell surface regulation of Hh during skeletal development and contribute to the development of strategies that enhance the osteogenic effect of Hh.

Free Research Field

骨軟骨生物学