Evaluation of the therapeutic benefits of anti-inflammatory M2 macrophage inducer for distraction osteogenesis

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15736
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima (2016); Nagoya University (2015)
• Principal Investigator: YAMAMOTO Akihito 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (50244083)
• Research Collaborator: KANO Fumiya 名古屋大学, 大学院医学系研究科口腔外科, 大学院生 ; ISHIKAWA Jun 名古屋大学, 大学院医学系研究科口腔外科, 大学院生
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 骨延長 / マクロファージ / 炎症

Outline of Final Research Achievements

Distraction osteogenesis (DO) successfully induces large-scale skeletal tissue regeneration, but it involves an undesirably long treatment period. A high-speed DO mouse model (H-DO) failed to generate new bone callus in the distraction gap. In this study, we showed that H-DO induced pro-inflammatory reaction in the gap. Importantly, we found that administration of anti-inflammatory M2 macrophage inducer, monocyte chemoattractant protein-1 (MCP-1) and the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (ED-Siglec-9), restored callus formation in the H-DO- gap.

Free Research Field

再生医学