2016 Fiscal Year Final Research Report
Localization and function of B cells in oral cancer
| Project/Area Number |
15K15742
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 口腔癌 / Ｂ細胞 / CXCL13 |
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| Outline of Final Research Achievements |
Recently, immunotherapy has attracted attention as a novel treatment with cancer, and immunocheck point inhibitors against T cells and antibodies inducing ADCC activity of NK cells are used in clinical setting. In this study, the significance of B cells in oral cancer was examined. Assessment of the relationship between the number of B cells in oral cancer tissues by immunohistochemical staining and the survival rate revealed that the prognosis was better as B cells more invaded the cancer stroma. Furthermore, CXCL13, a B cell attracting cytokine, was highly expressed in the cancerous tissues as compared with the adjacent normal tissues.
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| Free Research Field |
口腔外科学
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