Study on suppression of chemotherapy-induced oral mucositis by controlling intracellular receptors for cytotoxic factors

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15746
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: Hikiji Hisako 九州歯科大学, 歯学部, 教授 (50292876)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 口内炎

Outline of Final Research Achievements

Chemotherapy-induced oral mucositis is serious and unavoidable. Instead of the conventional symptomatic treatment, activation of the oral defending function is the most effective strategy for the severe oral mucositis.
We found a specific inflammatory reaction of the oral mucosa caused by the physical stimulation equivalent to that of the oral care during chemotherapy. Namely, we developed an in vivo experimental model of the oral care-induced reaction of oral mucosa using rats. We have shown that the internal environment of the subcutaneous tissue as well as the external environment was concerned with the mechanism of the reaction of oral mucosa.

Free Research Field

口腔外科学