2016 Fiscal Year Final Research Report
Epigenetic change due to occlusion
| Project/Area Number |
15K15760
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Showa University |
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Principal Investigator |
MAKI Koutaro 昭和大学, 歯学部, 教授 (80219295)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | メチル化 / 顎顔面外科手術 / エピジェネティック / EWAS / 咬合 |
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| Outline of Final Research Achievements |
We observed the influence of maxillofacial surgery on genome - wide methylation in saliva. Maxillofacial Surgery prior to surgery and 3 months after surgery, saliva of nine patients undergoing maxillofacial surgery and two controls were sampled. Genome-wide DNA methylation profiling was performed using Infinium Human Methylation 450 Beadchips. Significant (P <0.05) DNA methylation changes were observed in more than 10,000 sites between preoperative and postoperative.
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| Free Research Field |
歯科矯正学
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