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2016 Fiscal Year Final Research Report

Exploring the alternative pathology of periodontal disease by using ERAI mouse

Research Project

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Project/Area Number 15K15763
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionNiigata University

Principal Investigator

YAMAZAKI KAZUHISA  新潟大学, 医歯学系, 教授 (00182478)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywords小胞体ストレス応答 / 歯周組織破壊 / 歯周炎
Outline of Final Research Achievements

Endoplasmic reticulum (ER) stress is the cell response that activates the unfolded protein response (UPR) pathway in a variety of conditions, such as inflammation and bone metabolism.In order to clarify the exact location of the UPR response in periodontal tissues in periodontal disease, we induced periodontal tissue destraution by administering Porphyromonas gingivalis, a periodontopathic bacterium, and ligature placement around the upper second molar in ERAI mouse in which UPR reponse can be visualized. Although the upregulation of the UPR reponse-related gene was observed by using conventional method, this reponse cannot be visualized in ERAI mouse. We tried to detect UPR response visually in gingival tissue by administering tunicamysin, a UPR response-inducing agent or pancreas, consistently occurring UPR response as positive control experiments. However, we wereunable to detect UPR response visually.

Free Research Field

歯周病学

URL: 

Published: 2018-03-22  

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