2016 Fiscal Year Final Research Report
Development of molecular targeted drug for periodontitis based on the causative genes.
| Project/Area Number |
15K15768
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Periodontology
|
|---|
| Research Institution | Ohu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 歯周炎 / 生体外歯周炎モデル / HGF / miRNA |
|---|
| Outline of Final Research Achievements |
We have made a list of candidate genes for periodontitis using gene expression profiling data of in vitro periodontitis model which includes periodontitis causative fibroblasts. Inhibiting candidate genes products, collagen degradation was significantly decreased. It will make possible to molecular targeted therapy for periodontitis for the first time. We also demonstrated that periodontitis-causative fibroblasts are clearly different from normal gingival fibroblasts supported by RIKEN FANTOM5 Project, and established a detection method by PCR.
|
| Free Research Field |
生化学
|
