2016 Fiscal Year Final Research Report
Development of a bacteriophage therapy against periodontopathic microbiome
| Project/Area Number |
15K15773
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 口腔細菌叢 / 歯周病 |
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| Outline of Final Research Achievements |
We performed this study with a periodontitis-associated microbe, Filfactor alocis, as a target. First, we tried to isolate a F. alocis-specific bacteriophage from culture supernatant acquired from F. alocis continuous culture. This experiment still continues today.
Next, we performed an amino acids profiling of F. alocis culture supernatant, to know the influence of F. alocis on oral microbiome dysbiosis by secreting metabolites into the environment. It was revealed that 10 L-amino acids （Asn, Ser, Gly, Ala, Pro, Val, Ile, Leu, Phe, Lys）and 4 D-amino acids were secreted by F. alocis. This finding will provide clues about dysbiosis in oral microbiome.
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| Free Research Field |
予防歯科学
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